Targeted delivery of nanoparticles for the treatment of lung diseases

被引：363

作者：

Azarmi, Shirzad ^{[1
,2
]}

Roa, Wilson H. ^{[3
]}

Loebenberg, Raimar ^{[1
]}

机构：

[1] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

[2] Tabriz Univ Med Sci, Fac Pharm, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[3] Univ Alberta, Cross Canc Inst, Dept Oncol, Edmonton, AB T6G 2N8, Canada

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2008年 / 60卷 / 08期

基金：

加拿大健康研究院;

关键词：

pulmonary delivery; nanoparticle; lung cancer; tuberculosis; aerosol; colloidal delivery; nanotoxicology;

D O I：

10.1016/j.addr.2007.11.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Targeted delivery of drug molecules to organs or special sites is one of the most challenging research areas in pharmaceutical sciences. By developing colloidal delivery systems such as liposomes, micelles and nanoparticles a new frontier was opened for improving drug delivery. Nanoparticles with their special characteristics such as small particle size, large surface area and the capability of changing their surface properties have numerous advantages compared with other delivery systems. Targeted nanoparticle delivery to the lungs is an emerging area of interest. This article reviews research performed over the last decades on the application of nanoparticles administered via different routes of administration for treatment or diagnostic purposes. Nanotoxicological aspects of pulmonary delivery are also discussed. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：863 / 875

页数：13

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