Nanoparticles as antituberculosis drugs carriers: effect on activity against Mycobacterium tuberculosis in human monocyte-derived macrophages

被引：61

作者：

Anisimova, Y. V. ^{[1
]}

Gelperina, S. I. ^{[1
]}

Peloquin, C. A. ^{[1
]}

Heifets, L. B. ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Denver, CO 80206 USA

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2000年 / 2卷 / 02期

关键词：

tuberculosis; nanoparticles; antituberculosis drugs; Mycobacterium tuberculosis; drug delivery;

D O I：

10.1023/A:1010061013365

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This is the first report evaluating the nanoparticle delivery system for three antituberculosis drugs: isoniazid, rifampin, and streptomycin. The typical particle size is 250 nm. We studied accumulation of these drugs in human monocytes as well as their antimicrobial activity against Mycobacterium tuberculosis residing in human monocyte-derived macrophages. Nanoparticle encapsulation increased the intracellular accumulation (cell-association) of all three tested drugs, but it enhanced the antimicrobial activity of isoniazid and streptomycin only. On the other hand, the activity of encapsulated rifampin against intracellular bacteria was not higher than that of the free drug.

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页码：165 / 171

页数：7

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