Pathophysiology of changes in absolute lung volumes

被引:38
作者
Bancalari, E
Clausen, J
机构
[1] Univ Miami, Sch Med, Dept Pediat, Div Neonatol, Miami, FL 33101 USA
[2] Univ Calif San Diego, Dept Med, Div Pulm & Crit Care Med, La Jolla, CA 92093 USA
关键词
lung volume measurements; neonatology; paediatrics; physiology; pulmonary;
D O I
10.1183/09031936.98.12010248
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Changes in absolute lung volumes are common in lung disease and result in significant impacts on gas exchange, respiratory muscle function, the sensation of dyspnoea, and limitations to maximal exercise, Though our knowledge regarding the magnitude and determinants of changes in lung volumes in health and disease has increased in the past 20 Scars, a number of important questions remain unanswered. Consideration of the Limitations of specific methods for measuring lung volumes is essential when analysing published studies regarding absolute lung volumes in infants, children and adults, Though functional residual capacity is most commonly measured in children and adults with the subject awake and at rest, increasingly attention is being directed to making these measurements under clinically more relevant conditions (e.g. during exercise, sleep, anesthesia, or mechanical ventilation), The relationships between dynamic changes in functional residual capacity, Row limitation during tidal breaths, sensation of dyspnoea and exercise limitation are important to understand, and are the focus of current and future research, Improved understanding of these relationships mar lead to improvements in therapy of patients with acute and chronic lung disease and are likely to be particularly important for evaluating the efficacy of and optimal patient selection for new modes of therapy, such as lung volume reduction surgery.
引用
收藏
页码:248 / 258
页数:11
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