Stereoselective cyanation of chiral α-amino aldehydes by reaction with Nagata's reagent:: a route to enantiopure β-amino-α-hydroxy acids

被引：37

作者：

Andrés, JM ^{[1
]}

Martínez, MA ^{[1
]}

Pedrosa, R ^{[1
]}

Pérez-Encabo, A ^{[1
]}

机构：

[1] Univ Valladolid, Fac Ciencias, Dept Quim Organ, E-47011 Valladolid, Spain

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0957-4166(01)00044-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral alpha -dibenzylamino aldehydes react with diethylaluminum cyanide leading to anti-beta -dibenzylamino-alpha -hydroxy-cyanides as the major diastereoisomers in good yields and diastereomeric excesses. Hydrolysis of the nitrile derivatives allows the synthesis of enantiopure beta -amino-alpha -hydroxy acids. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：347 / 353

页数：7

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