A concise synthesis of aza-dipeptide isosteres.

被引：20

作者：

Fässler, A

Bold, G

Steiner, H

机构：

[1] Nova Pharmaceut Corp, Cent Res Labs, Macclesfield SK10 2NX, Cheshire, England

[2] Novartis AG, Sector Pharma, Med Chem Oncol, CH-4002 Basel, Switzerland

[3] Novartis Serv, Catalysis & Synth Serv, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 27期

关键词：

cyanohydrins; hydrazides; hydrogenation; rearrangement;

D O I：

10.1016/S0040-4039(98)00897-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aza-dipeptide isosteres as potent HIV-protease inhibitors containing a (hydroxyethyl)-hydrazine moiety are synthesised in >98% diastereomeric and enantiomeric purity starting from (L)-phenylalanine aldehyde. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：4925 / 4928

页数：4

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