New approaches to the asymmetric synthesis of dipeptide isosteres via β-lactam synthon method

被引：23

作者：

Ojima, I ^{[1
]}

Wang, H ^{[1
]}

Wang, T ^{[1
]}

Ng, EW ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(97)10677-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New and efficient synthetic routes to dipeptide isosteres with high enantiomeric purity, e.g., hydroxyethylene, dihydroxyethylene and hydroxyethylamine isosteres, have been developed via oxiranes 6 and formyloxazolines 13 derived from N-t-Boc-beta-lactams 4. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：923 / 926

页数：4

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