A HIGHLY EFFICIENT ROUTE TO TAXOTERE BY THE BETA-LACTAM SYNTHON METHOD

被引：134

作者：

OJIMA, I

SUN, CM

ZUCCO, M

PARK, YH

DUCLOS, O

KUDUK, S

机构：

[1] Department of Chemistry, State University of New York at Stony Brook, Stony Brook

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 26期

关键词：

D O I：

10.1016/S0040-4039(00)60514-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Taxotere, a highly promising anticancer drug, is synthesized through an efficient coupling of 7,10-diTroc-10-deacetylbaccatin III with enantiomerically pure (3R,4S)-1-(t)BOC-3-EEO-4-phenylazetidin-2-one which is obtained via chiral ester enolate - imine cyclocondensation.

引用

页码：4149 / 4152

页数：4

共 18 条

[1]

BISSERY MC, 1991, CANCER RES, V51, P4845

[2]

BISSET D, 1992, P AM ASSOC CANC RES, V33, P3145

[3]

BURRIS H, 1992, P AN M AM SOC CLIN, V11, P369

[4] IMPROVED PROTECTION AND ESTERIFICATION OF A PRECURSOR OF THE TAXOTERE(R) AND TAXOL SIDE-CHAINS [J].

COMMERCON, A ;

BEZARD, D ;

BERNARD, F ;

BOURZAT, JD .

TETRAHEDRON LETTERS, 1992, 33 (36) :5185-5188

[5] A HIGHLY EFFICIENT, PRACTICAL APPROACH TO NATURAL TAXOL [J].

DENIS, JN ;

GREENE, AE ;

GUENARD, D ;

GUERITTEVOEGELEIN, F ;

MANGATAL, L ;

POTIER, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (17) :5917-5919

[6] SYNTHESIS OF BIOLOGICALLY-ACTIVE TAXOL ANALOGS WITH MODIFIED PHENYLISOSERINE SIDE-CHAINS [J].

GEORG, GI ;

CHERUVALLATH, ZS ;

HIMES, RH ;

MEJILLANO, MR ;

BURKE, CT .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (22) :4230-4237

[7]

Holton R. A., 1990, Method for preparation of taxol., Patent No. [EP 0400971 A2, 0400971, EP400971, 400971]

[8]

Jung M. J., 1985, CHEM BIOCH AMINO ACI, P227

[9]

KEPLER JA, 2ND NAT CANC I WORKS

[10]

LAVELLE F, 1989, Proceedings of the American Association for Cancer Research Annual Meeting, V30, P566

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