Serum and urine levels of tamoxifen and its metabolites in patients with advanced breast cancer after a loading dose and at steady-state levels

被引：10

作者：

de Vos, D

Slee, PHTJ

Briggs, RJ

Stevenson, D

机构：

[1] Med Dept Pharmachem BV, NL-2003 RN Haarlem, Netherlands

[2] St Antonius Hosp, NL-3435 CM Nieuwegein, Netherlands

[3] Univ Surrey, Sch Biol Sci, Robens Analyt Ctr, Guildford GU2 5XH, Surrey, England

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1998年 / 42卷 / 06期

关键词：

tamoxifen; serum levels; urinary excretion; loading dose; steady state;

D O I：

10.1007/s002800050854

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: To compare serum and urine levels of tamoxifen and metabolites after a loading dose and at the steady state. Methods: A loading dose of 160 mg of tamoxifen was given to 14 patients with advanced breast cancer. Thereafter a regular daily dose of 30 mg of tamoxifen was given. Serum and urine levels of tamoxifen and metabolites were measured by high-performance liquid chromatography and compared with levels determined in 31 patients with advanced breast cancer at the steady state at a daily dose of 30 mg of tamoxifen. Results: Serum and urine levels (24-h values) of tamoxifen and metabolites were lower (P < 0.05) after a loading dose than at the steady state. The difference was most pronounced for the metabolites, whereas the tamoxifen loading-dose level was near the steady state. Conclusion: Tamoxifen steady state can be reached in 1-2 days by the administration of a loading dose of 160 mg of tamoxifen for 2 days. Tamoxifen metabolite steady-state levels are reached regularly after 4 or more weeks during application of a loading dose. Very little tamoxifen or metabolites are excreted into the urine.

引用

页码：512 / 514

页数：3

共 19 条

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