Synthetic studies of halichondrin B, an antitumor polyether macrolide isolated from a marine sponge .5. A highly concise and efficient synthesis of the C-37 approximate to C-54 tricyclic JKL-ring part

被引：21

作者：

Horita, K

Hachiya, S

Ogihara, K

机构：

[1] Faculty of Pharmaceutical Sciences, Hokkaido University

来源：

HETEROCYCLES | 1996年 / 42卷 / 01期

关键词：

D O I：

10.3987/COM-95-S30

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and efficient synthesis of C(37)similar to C-54 tricyclic JKL-ring unit (2) of halichondrin B (1) utilizing C-2-symmetric spiroketal derivative (5) as a synthetic key intermediate, easily provided from dimethyl L-(+)-tartrate, is reported.

引用

页码：99 / 104

页数：6

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