A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outside Africa

被引：50

作者：

Alonso, S ^{[1
]}

Armour, JAL ^{[1
]}

机构：

[1] Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2UH, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1073/pnas.011244998

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have sequenced a highly polymorphic subterminal noncoding region from human chromosome 16p13.3, flanking the 5' end of the hypervariable minisatellite MS205, in 100 chromosomes sampled from different African and Euroasiatic populations. Coalescence analysis indicates that the time to the most recent common ancestor (approximately 1 million years) predates the appearance of anatomically modern human forms. The root of the network describing this variability lies in Africa. African populations show a greater level of diversity and deeper branches. Most Euroasiatic variability seems to have been generated after a recent out-of-Africa range expansion. A history of population growth is the most likely scenario for the Euroasiatic populations. This pattern of nuclear variability can be reconciled with inferences based on mitochondrial DNA.

引用

页码：864 / 869

页数：6

共 47 条

[21] Distribution of haplotypes from a chromosome 21 region distinguishes multiple prehistoric human migrations [J].