Effectiveness of 1,25-dihydroxyvitamin D supplementation on blood pressure reduction in a pseudohypoparathyroidism patient with high renin activity

被引：46

作者：

Kimura, Y ^{[1
]}

Kawamura, M ^{[1
]}

Owada, M ^{[1
]}

Oshima, T ^{[1
]}

Murooka, M ^{[1
]}

Fujiwara, T ^{[1
]}

Hiramori, K ^{[1
]}

机构：

[1] Iwate Med Univ, Dept Internal Med 2, Morioka, Iwate, Japan

来源：

INTERNAL MEDICINE | 1999年 / 38卷 / 01期

关键词：

hypertension; calcitriol; parathyroid hormone; calcium;

D O I：

10.2169/internalmedicine.38.31

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 42-year-old man had biochemical and somatic abnormalities compatible with pseudohypoparathyroidism type I (PsHP) and also had high plasma renin activity (PRA). After 1,25-dihydroxyvitamin D (calcitriol) supplementation the systolic/diastolic blood pressure, assessed by 24-hour non-invasive ambulatory blood pressure monitoring, was reduced from 145/96 mmHg to 128/85 mmHg with normalization of the serum calcium level and its related hormones, as well as decreased PRA, Calcitriol supplementation successfully reduced the blood pressure in this patient with PsHP and a high PRA, suggesting that calcium-related hormones and/or the renin-angiotensin system were involved in lowering the blood pressure.

引用

页码：31 / 35

页数：5