Mitochondrial transcription factor A in the maintenance of mitochondrial DNA - Oeverview of its multiple roles

被引：100

作者：

Kang, D ^{[1
]}

Hamasaki, N ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Clin Chem & Lab Med, Higashi Ku, Fukuoka 8128582, Japan

来源：

ROLE OF THE MITOCHONDRIA IN HUMAN AGING AND DISEASE: FROM GENES TO CELL SIGNALING | 2005年 / 1042卷

关键词：

mitochondria; mitochondrial DNA; mitochondrial transcription factor A; TEAM; reactive oxygen species; ROS; transcription; replication; DNA repair;

D O I：

10.1196/annals.1338.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria have their own genome, which is essential for proper oxidative phosphorylation needed for a large part of ATP production in a cell. Although mitochondrial DNA-less (rho(0)) cells can survive under special conditions, the integrity of the mitochondrial genome is critical for survival of multicellular organisms. Mitochondrial transcription factor A (TFAM), originally cloned as transcription factor, is essential for the maintenance of mtDNA. Recently, it has become known that TFAM plays critical roles in multiple aspects to maintain the integrity of mitochondrial DNA: transcription, replication, nucleoid formation, damage sensing, and DNA repair. The effects of TFAM in these aspects are intimately related to each other and to function as a whole for the purpose of maintenance of mtDNA.

引用

页码：101 / 108

页数：8

共 53 条

[1] Human mitochondrial DNA is packaged with TFAM [J].

Alam, TI ;

Kanki, T ;

Muta, T ;

Ukaji, K ;

Abe, Y ;

Nakayama, H ;

Takio, K ;

Hamasaki, N ;

Kang, DC .

NUCLEIC ACIDS RESEARCH, 2003, 31 (06) :1640-1645

[2] ASSOCIATION OF A PROTEIN-STRUCTURE OF PROBABLE MEMBRANE DERIVATION WITH HELA-CELL MITOCHONDRIAL-DNA NEAR ITS ORIGIN OF REPLICATION [J].

ALBRING, M ;

GRIFFITH, J ;

ATTARDI, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (04) :1348-1352

[3] OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].

AMES, BN ;

SHIGENAGA, MK ;

HAGEN, TM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922

[4] MITOCHONDRIAL MUTATIONS MAY INCREASE OXIDATIVE STRESS - IMPLICATIONS FOR CARCINOGENESIS AND AGING [J].

BANDY, B ;

DAVISON, AJ .

FREE RADICAL BIOLOGY AND MEDICINE, 1990, 8 (06) :523-539

[5]

Beckman K B, 1996, Methods Enzymol, V264, P442, DOI 10.1016/S0076-6879(96)64040-3

[6] Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone [J].

Bowmaker, M ;

Yang, MY ;

Yasukawa, T ;

Reyes, A ;

Jacobs, HT ;

Huberman, JA ;

Holt, IJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (51) :50961-50969

[7] CHARACTERIZATION OF A HISTONE-LIKE PROTEIN EXTRACTED FROM YEAST MITOCHONDRIA [J].

CARON, F ;

JACQ, C ;

ROUVIEREYANIV, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (09) :4265-4269

[8] ADDITION OF A 29-RESIDUE CARBOXYL-TERMINAL TAIL CONVERTS A SIMPLE HMG BOX-CONTAINING PROTEIN TRANSCRIPTIONAL ACTIVATOR [J].

DAIRAGHI, DJ ;

SHADEL, GS ;

CLAYTON, DA .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 249 (01) :11-28

[9] INSITU PHOTOCHEMICAL CROSSLINKING OF HELA-CELL MITOCHONDRIAL-DNA BY A PSORALEN DERIVATIVE REVEALS A PROTECTED REGION NEAR THE ORIGIN OF REPLICATION [J].

DEFRANCESCO, L ;

ATTARDI, G .

NUCLEIC ACIDS RESEARCH, 1981, 9 (22) :6017-6030

[10] A CLOSE RELATIVE OF THE NUCLEAR, CHROMOSOMAL HIGH-MOBILITY GROUP PROTEIN HMG1 IN YEAST MITOCHONDRIA [J].

DIFFLEY, JFX ;

STILLMAN, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7864-7868

← 1 2 3 4 5 6 →