Processing and presentation of antigens by dendritic cells: implications for vaccines

被引：71

作者：

Bhardwaj, N ^{[1
]}

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 09期

关键词：

D O I：

10.1016/S1471-4914(01)02101-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Dendritic cells (DCs) are potent antigen-presenting cells that are specialized in initiation of T-cell immunity. DCs induce promising anti-tumor T-cell and clinical responses, apparently without significant toxicity. Under certain conditions, DCs even silence T-cell immune responses in vivo. This dual capacity to modulate the immune system uniquely positions DCs for the treatment of autoimmunity, cancer and chronic viral infections.

引用

收藏

页码：388 / 394

页数：7

相关论文

共 73 条

[1]

Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].

Albert, ML ;

Sauter, B ;

Bhardwaj, N .

NATURE, 1998, 392 (6671) :86-89

[2]

Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[3]

Will the making of plasmacytoid dendritic cells in vitro help unravel their mysteries?: Commentary [J].

Banchereau, J ;

Pulendran, B ;

Steinman, R ;

Palucka, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (12) :F39-F44

[4]

INACTIVATED INFLUENZA-VIRUS, WHEN PRESENTED ON DENDRITIC CELLS, ELICITS HUMAN CD8(+) CYTOLYTIC T-CELL RESPONSES [J].

BENDER, A ;

BUI, LK ;

FELDMAN, MAV ;

LARSSON, M ;

BHARDWAJ, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (06) :1663-1671

[5]

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood [J].

Bender, A ;

Sapp, M ;

Schuler, G ;

Steinman, RM ;

Bhardwaj, N .

JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 196 (02) :121-135

[6]

Induction of a CD8(+) cytotoxic T lymphocyte response by cross-priming requires cognate CD4(+) T cell help [J].

Bennett, SRM ;

Carbone, FR ;

Karamalis, F ;

Miller, JFAP ;

Heath, WR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (01) :65-70

[7]

CROSS-PRIMING FOR A SECONDARY CYTOTOXIC RESPONSE TO MINOR H-ANTIGENS WITH H-2 CONGENIC CELLS WHICH DO NOT CROSS-REACT IN CYTOTOXIC ASSAY [J].

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1976, 143 (05) :1283-1288

[8]

SMALL AMOUNTS OF SUPERANTIGEN, WHEN PRESENTED ON DENDRITIC CELLS, ARE SUFFICIENT TO INITIATE T-CELL RESPONSES [J].

BHARDWAJ, N ;

YOUNG, JW ;

NISANIAN, AJ ;

BAGGERS, J ;

STEINMAN, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :633-642

[9]

Generation of interferon α-producing predendritic cell (Pre-DC)2 from human CD34+ hematopoietic stem cells [J].

Blom, B ;

Ho, S ;

Antonenko, S ;

Liu, YJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (12) :1785-1795

[10]

Massive expansion of antigen-specific CD8+ T cells during an acute virus infection [J].

Butz, EA ;

Bevan, MJ .

IMMUNITY, 1998, 8 (02) :167-175

← 1 2 3 4 5 6 7 8 →