Mannheimia (Pasteurella) haemolytica leukotoxin binding domain lies within amino acids 1 to 291 of bovine CD18

被引：18

作者：

Gopinath, RS ^{[1
]}

Arnbagala, TC ^{[1
]}

Deshpande, MS ^{[1
]}

Donis, RO ^{[1
]}

Srikumaran, S ^{[1
]}

机构：

[1] Univ Nebraska, Dept Vet & Biomed Sci, Lincoln, NE 68583 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 09期

关键词：

D O I：

10.1128/IAI.73.9.6179-6182.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previously, we identified bovine CD18 as the receptor for leukotoxin secreted by Mannheimia (Pasteurella) haemolytica. In this study, we constructed bovine-murine CD18 chimeras to locate the leukotoxin binding domain on CD18. Leukotoxin specifically lysed transfectants expressing bovine CD18 fragment encompassing amino acids 1 to 291, indicating that leukotoxin binding domain lies within amino acids I to 291 of bovine CD18.

引用

页码：6179 / 6182

页数：4

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