Trifluoromethyl ethers - synthesis and properties of an unusual substituent

被引：244

作者：

Leroux, Frederic R. ^{[1
]}

Manteau, Baptiste ^{[1
]}

Vors, Jean-Pierre ^{[2
]}

Pazenok, Sergiy ^{[3
]}

机构：

[1] Univ Strasbourg, CNRS, Lab Stereochim, F-67087 Strasbourg 2, France

[2] Bayer CropSci SA, Ctr Rech La Dargoire, F-69009 Lyon, France

[3] Bayer CropSci AG, D-40789 Monheim, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 4卷

关键词：

D O I：

10.3762/bjoc.4.13

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent.

引用

页数：15

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