Competing for the Clamp: Promoting RNA Polymerase Processivity and Managing the Transition from Initiation to Elongation

被引：15

作者：

Hartzog, Grant A. ^{[1
]}

Kaplan, Craig D. ^{[2
]}

机构：

[1] Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA

[2] Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA

来源：

MOLECULAR CELL | 2011年 / 43卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

TRANSCRIPTION ELONGATION; COMPLEX; RFAH;

D O I：

10.1016/j.molcel.2011.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription elongation factor NusG/Spt5 spans the central cleft of RNA polymerase and functionally competes with transcription initiation factors. This work highlights the RNA polymerase clamp as a target for regulation and points to dynamic interactions between initiation and elongation machineries.

引用

页码：161 / 163

页数：3

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