2-(anilinomethyl)imidazolines as α1-adrenoceptor agonists:: The identification of α1A subtype selective 2′-carboxylic acid esters and amides

被引：6

作者：

Bishop, MJ ^{[1
]}

Berman, J ^{[1
]}

Bigham, EC ^{[1
]}

Garrison, DT ^{[1
]}

Gobel, MJ ^{[1
]}

Hodson, SJ ^{[1
]}

Irving, PE ^{[1
]}

Liacos, JA ^{[1
]}

Minick, DJ ^{[1
]}

Navas, F ^{[1
]}

Saussy, DL ^{[1
]}

Speake, JD ^{[1
]}

机构：

[1] GlaxoSmithKline, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(01)00569-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha (1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency. efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha (1A)-subtype selective agonists have been identified. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2871 / 2874

页数：4

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