Cell proliferation in gastrointestinal mucosa

被引：73

作者：

Wong, WM ^{[1
]}

Wright, NA ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Histopathol, London W12 0NN, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1999年 / 52卷 / 05期

关键词：

gastrointestinal mucosa; cell proliferation; stem cells;

D O I：

10.1136/jcp.52.5.321

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gastrointestinal cell proliferation plays an important role in the maintenance of the integrity of the gastrointestinal system. The study of gastrointestinal proliferation kinetics allows a better understanding of the complexity of the system, and also has important implications for the study of gastrointestinal carcinogenesis. Gastrointestinal stem cells are shown to be pluripotential and to give rise to all cell lineages in the epithelium. Carcinogenesis in the colon occurs through sequential mutations, possibly occurring in a single cell-the stem cell.

引用

页码：321 / 333

页数：13

共 148 条

[1] THE EFFECT OF A SINGLE INJECTION OF CYTOSINE-ARABINOSIDE ON CELL-POPULATION KINETICS IN THE MOUSE JEJUNAL CRYPT [J].

ALDEWACHI, HS ;

WRIGHT, NA ;

APPLETON, DR ;

WATSON, AJ .

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1980, 34 (03) :299-309

[2]

ALDEWACHI HS, 1975, J ANAT, V119, P105

[3] EFFECT OF A SINGLE INJECTION OF HYDROXYUREA ON CELL-POPULATION KINETICS IN SMALL BOWEL MUCOSA OF RAT [J].

ALDEWACHI, HS ;

WRIGHT, NA ;

APPLETON, DR ;

WATSON, AJ .

CELL AND TISSUE KINETICS, 1977, 10 (03) :203-213

[4]

ALMUKHTAR MYT, 1982, MECHANISMS INTESTINA, P243

[5] INFLUENCE OF STARVATION AND REFEEDING ON MUCOSAL SIZE AND EPITHELIAL RENEWAL IN RAT SMALL-INTESTINE [J].

ALTMANN, GG .

AMERICAN JOURNAL OF ANATOMY, 1972, 133 (04) :391-+

[6] INFLUENCE OF DIETARY CALCIUM AND VITAMIN-D ON COLON EPITHELIAL-CELL PROLIFERATION AND 1,2-DIMETHYLHYDRAZINE-INDUCED COLON CARCINOGENESIS IN RATS FED HIGH-FAT DIETS [J].

BEATY, MM ;

LEE, EY ;

GLAUERT, HP .

JOURNAL OF NUTRITION, 1993, 123 (01) :144-152

[7] RADIOTOXICITY OF INCORPORATED [H-3]THYMIDINE - CONSEQUENCES FOR THE INTERPRETATION OF FLM DATA OF IRRADIATED CELL-POPULATIONS [J].

BECK, HP .

CELL AND TISSUE KINETICS, 1982, 15 (05) :469-472

[8]

BLEIBERG H, 1970, GASTROENTEROLOGY, V58, P851

[9]

Bostick RM, 1997, CANCER EPIDEM BIOMAR, V6, P1011

[10] CALCIUM AND COLORECTAL EPITHELIAL-CELL PROLIFERATION - A PRELIMINARY RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED CLINICAL-TRIAL [J].

BOSTICK, RM ;

POTTER, JD ;

FOSDICK, L ;

GRAMBSCH, P ;

LAMPE, JW ;

WOOD, JR ;

LOUIS, TA ;

GANZ, R ;

GRANDITS, G .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (02) :132-141

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