Cell proliferation in gastrointestinal mucosa

被引：73

作者：

Wong, WM ^{[1
]}

Wright, NA ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Histopathol, London W12 0NN, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1999年 / 52卷 / 05期

关键词：

gastrointestinal mucosa; cell proliferation; stem cells;

D O I：

10.1136/jcp.52.5.321

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gastrointestinal cell proliferation plays an important role in the maintenance of the integrity of the gastrointestinal system. The study of gastrointestinal proliferation kinetics allows a better understanding of the complexity of the system, and also has important implications for the study of gastrointestinal carcinogenesis. Gastrointestinal stem cells are shown to be pluripotential and to give rise to all cell lineages in the epithelium. Carcinogenesis in the colon occurs through sequential mutations, possibly occurring in a single cell-the stem cell.

引用

页码：321 / 333

页数：13

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