Neutralizing antibodies to human and simian adenoviruses in humans and New-World monkeys

被引：57

作者：

Ersching, Jonatan ^{[1
]}

Hernandez, Malva I. M. ^{[2
]}

Cezarotto, Fabrizzio S. ^{[3
]}

Ferreira, Jovino D. S. ^{[4
]}

Martins, Amely B. ^{[5
]}

Switzer, William M. ^{[7
]}

Xiang, Zhiquan ^{[6
]}

Ertl, Hildegund C. J. ^{[6
]}

Zanetti, Carlos R. ^{[1
]}

Pinto, Aguinaldo R. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Microbiol Imunol & Parasitol, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Ecol & Zool, BR-88040900 Florianopolis, SC, Brazil

[3] Ctr Hematol & Hemoterapia Acre, BR-69914500 Rio Branco, AC, Brazil

[4] Univ Fed Santa Catarina, Hosp Univ Polydoro Ernani Sao Thiago, BR-88040900 Florianopolis, SC, Brazil

[5] Ctr Nacl Pesquisa & Conservacao Primatas Brasilei, BR-58010480 Joao Pessoa, Paraiba, Brazil

[6] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[7] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

来源：

VIROLOGY | 2010年 / 407卷 / 01期

关键词：

Human adenovirus; Simian adenovirus; Neutralizing antibody; Seroneutralization assay; Vaccines; SUB-SAHARAN AFRICA; VACCINE VECTORS; SEROTYPE; 5; IMMUNOGENICITY; SEROPREVALENCE; IMMUNIZATION; PREVALENCE; IMMUNITY; TYPE-5; INDUCTION;

D O I：

10.1016/j.virol.2010.07.043

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaccines based on adenovirus (Ad) vectors are currently in development against several pathogens. However, neutralizing antibodies (NAb) to human adenovirus type 5 (AdHu5), the best-studied vector, are highly prevalent in humans worldwide. Less-prevalent adenoviruses, including human and simian serotypes, provide alternative vaccine platforms. In this study, sera from 200 Brazilian human subjects and New-World monkeys were tested for NAb titers to human serotypes AdHu5 and AdHu26 and chimpanzee-origin Ad viruses of serotype 6 (AdC6) and serotype 68 (AdC68). Seroprevalence rates of NAb in humans were 69.5% for AdHu5, 44% for AdHu26, 21% for AdC6 and 23.5% for AdC68. In addition, NAb titers to human Ad were consistently higher than those found to simian serotypes. Surprisingly, sera from some New-World monkey species were able to neutralize AdC6 and/or AdC68. A possible explanation for these findings and the implications for the development of Ad-vector vaccines are discussed in detail. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1 / 6

页数：6

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