Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones

被引：16

作者：

Barraja, P

Sciabica, L

Diana, P

Lauria, A

Montalbano, A

Almerico, AM

Dattolo, G

Cirrincione, G

Disarò, S

Basso, G

Viola, G

Dall'Acqua, F

机构：

[1] Univ Palermo, Dipartimento Fharmacochim Tossicol & Biol, I-90123 Palermo, Italy

[2] Univ Padua, Dipartimento Pediat, I-35131 Padua, Italy

[3] Univ Padua, Dipartimento Sci Farmaceut, I-35131 Padua, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 09期

关键词：

thiopyrano-indoles; photochemotherapeutic activity; apoptosis induction;

D O I：

10.1016/j.bmcl.2005.03.016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong anti-proliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2291 / 2294

页数：4

共 12 条

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