Embryonic expression of the murine homologue of SALL1, the gene mutated in Townes-Brocks syndrome

被引：55

作者：

Buck, A

Kispert, A

Kohlhase, J

机构：

[1] Univ Gottingen, Inst Humangenet, D-37073 Gottingen, Germany

[2] Max Planck Inst Immunobiol, D-79108 Freiburg, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 104卷 / 1-2期

关键词：

spalt; sal; Townes-Brocks syndrome; limb; mouse embryo;

D O I：

10.1016/S0925-4773(01)00364-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SALL1 is one of three human homologues of the Drosophila region-specific homeotic gene spats (sal). Mutations of SALL1 on chromosome 16q12.1 cause Townes-Brocks syndrome (TBS) which is characterized by defects in multiple organ systems including limbs, ears, kidneys and anus. Here, we have analyzed the expression of the mouse homologue of SALL1 (Sall1) during early embryogenesis. Sall1 expression is very prominent in the developing brain and the limbs. Other sites of expression include the meso- and metanephros, lens, olfactory bulbs, heart, primitive streak and the genital tubercle. Hence, Sall1 expression to a large degree reflects the structures affected in human TBS. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 146

页数：4

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