Synthesis of α-(3-indolyl)glycine derivatives via spontaneous Friedel-Crafts reaction between indoles and glyoxylate imines

被引：48

作者：

Jiang, B ^{[1
]}

Huang, ZG ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2005年 / 13期

关键词：

Friedel-Crafts reaction; indolyl glycine; indole derivative; glyoxylate imine; spontaneous reaction;

D O I：

10.1055/s-2005-869978

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mannich-type Friedel-Crafts reaction between indoles and ethyl glyoxylate imines proceeded spontaneously in the absence of an acid catalyst. Ethyl alpha-(3-indolyl)glycinates were obtained in moderate to high yields. Reaction with (R)-alpha-methylbenzylamine derived imine afforded chiral alpha-(3-indolyl)glycinates with good diastereoselectivities (up to 96:4).

引用

页码：2198 / 2204

页数：7

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