The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug; resistance. preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability. and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model. which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
机构:Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
Dvorák, M
Kopecková, P
论文数: 0引用数: 0
h-index: 0
机构:Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
Kopecková, P
Kopecek, J
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
机构:Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
Dvorák, M
Kopecková, P
论文数: 0引用数: 0
h-index: 0
机构:Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
Kopecková, P
Kopecek, J
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA