学术探索
学术期刊
新闻热点
数据分析
智能评审

Water soluble polymers in tumor targeted delivery

被引：192
作者：
Kopecek, J
Kopecková, P
Minko, T
Lu, ZR
Peterson, CM
机构：
[1] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
[2] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA
[3] Univ Utah, Dept Obstet & Gynecol, Salt Lake City, UT 84112 USA
来源：
JOURNAL OF CONTROLLED RELEASE | 2001年 / 74卷 / 1-3期
关键词：
HPMA copolymers; PK1; ovarian carcinoma; antibody fragments; long-circulating macromolecular therapeutics; combination therapy; photodynamic therapy;
D O I：
10.1016/S0168-3659(01)00330-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug; resistance. preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability. and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model. which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：147 / 158
页数：12
相关论文
共 72 条
  • [11] Efficacy and safety of stealth liposomal doxorubicin in AIDS-related Kaposi's sarcoma
    Goebel, FD
    Goldstein, D
    Goos, M
    Jablonowski, H
    Stewart, JS
    [J]. BRITISH JOURNAL OF CANCER, 1996, 73 (08) : 989 - 994
  • [12] HOW DOES PHOTODYNAMIC THERAPY WORK
    HENDERSON, BW
    DOUGHERTY, TJ
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1992, 55 (01) : 145 - 157
  • [13] Hershfield MS, 1997, ACS SYM SER, V680, P145
  • [14] Pegaspargase: An alternative?
    Holle, LM
    [J]. ANNALS OF PHARMACOTHERAPY, 1997, 31 (05) : 616 - 624
  • [15] AN EIN KOLLOIDALES BLUTPLASMA-ERSATZMITTEL (POLYVINYLPYRROLIDON) GEBUNDENES PEPTAMIN (GLYCYL-L-LEUCYL-MEZCALIN) ALS NEUARTIGE DEPOTFORM FUR BIOLOGISCH AKTIVE PRIMARE AMINE (MEZCALIN)
    JATZKEWITZ, H
    [J]. ZEITSCHRIFT FUR NATURFORSCHUNG PART B-CHEMIE BIOCHEMIE BIOPHYSIK BIOLOGIE UND VERWANDTEN GEBIETE, 1955, 10 (01): : 27 - 31
  • [16] Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine
    Julyan, PJ
    Seymour, LW
    Ferry, DR
    Daryani, S
    Boivin, CM
    Doran, J
    David, M
    Anderson, D
    Christodoulou, C
    Young, AM
    Hesslewood, S
    Kerr, DJ
    [J]. JOURNAL OF CONTROLLED RELEASE, 1999, 57 (03) : 281 - 290
  • [17] HPMA copolymer-anticancer drug conjugates:: design, activity, and mechanism of action
    Kopecek, J
    Kopecková, P
    Minko, T
    Lu, ZR
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2000, 50 (01) : 61 - 81
  • [18] CONTROLLED BIODEGRADABILITY OF POLYMERS - A KEY TO DRUG DELIVERY SYSTEMS
    KOPECEK, J
    [J]. BIOMATERIALS, 1984, 5 (01) : 19 - 25
  • [19] TARGETABLE PHOTOACTIVATABLE POLYMERIC DRUGS
    KOPECEK, J
    RIHOVA, B
    KRINICK, NL
    [J]. JOURNAL OF CONTROLLED RELEASE, 1991, 16 (1-2) : 137 - 143
  • [20] KOPECEK J, 1981, MAKROMOL CHEM, V182, P2941
12345678