Functional magnetic resonance imaging during pantomiming tool-use gestures

被引:121
作者
Choi, SH
Na, DL
Kang, E
Lee, KM
Lee, SW
Na, DG
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol,Kangnam Ku, Seoul 135710, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea
[3] Inha Univ, Coll Med, Dept Neurol, Inchon, South Korea
[4] Seoul Natl Univ Hosp, Dept Nucl Med, Seoul 110744, South Korea
[5] Seoul Natl Univ Hosp, Dept Neurol, Seoul 110744, South Korea
关键词
functional magnetic resonance imaging; praxis; parietal lobe; human;
D O I
10.1007/s002210100777
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The purpose of this study was to identify the functional fields activated in relation to gestural movements. Using functional magnetic resonance imaging (fMRI), we mapped brain activity in ten right-handed, normal volunteers during activation and control tasks. The activation condition consisted of pantomiming tool-use gestures with either the left hand or right hand, whereas the control condition comprised repetitive, oppositional movements between thumb and index finger. Activated cortical regions were highly lateralized to the left hemisphere during pantomiming of tool use regardless of hand used. Praxis with either hand commonly activated the superior parietal lobule, supplementary motor area, premotor area of the left hemisphere, and cerebellar vermis. However, minimal activation occurred in the inferior parietal lobule, which has been known to be a critical area for praxis generation. Compared with left-hand praxis, right-hand praxis exhibited additional activation in the left putamen and posterior part of the left inferior temporal region. Our findings concur with neuropsychological observations that the left hemisphere in right-handers mediates programming and executing skilled movements and that, within the left hemisphere, praxis is predominantly subserved by the parietal lobe, supplementary motor area, and premotor area. However, unlike previous lesion studies, the results of our fMRI study suggested that the superior parietal lobule more likely than the inferior parietal lobule play an important role in gesture production.
引用
收藏
页码:311 / 317
页数:7
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