Do different types of liver lesions differ in their uptake of the microbubble contrast agent SHU 508A in the late liver phase? Early experience

被引:83
作者
Blomley, MJK
Sidhu, PS
Cosgrove, DO
Albrecht, T
Harvey, CJ
Heckemann, RA
Butler-Barnes, J
Eckersley, RJ
Basilico, R
机构
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med, Dept Imaging, London W12 0HS, England
[2] Kings Coll Hosp London, Dept Radiol, London, England
[3] Free Univ Berlin, Klinikum Benjamin Franklin, Dept Radiol, D-12200 Berlin, Germany
[4] Univ G dAnnunzio, Dept Radiol, Chieti, Italy
关键词
liver neoplasms; diagnosis; liver neplasms; US; ultrasound; (US); contrast media;
D O I
10.1148/radiol.2203992044
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];
摘要
PURPOSE: To compare the uptake of SH U 508A in different types of liver lesions by using stimulated acoustic emission. MATERIALS AND METHODS: Thirty-seven patients with characterized lesions (metastasis, n = 17; hepatocellular carcinoma, n = 4; hemangioma, n = 9; focal nodular hyperplasia, n = 7) received 2.5 g SH U 508A. After 5 minutes, stimulated acoustic emission was elicited by using a previously described method. Liver and/or lesional differences were assessed with videodensitometry (objective conspicuity score), and two observers assessed each lesion by using a six-point scale (subjective conspicuity score). RESULTS: Metastases and hepatocellular carcinoma had low stimulated acoustic emission; median objective conspicuity scores were 70% and 68% (all scores were greater than or equal to 43%), respectively, and subjective conspicuity scores were 2 or higher for both observers. Hemangiomas had reduced stimulated acoustic emission, with more variability; the median objective conspicuity score was 41% (range, 9%-72%), and the median subjective conspicuity scores were 2 (range, 1-4) and 3.5 (range, 1-5) for observers I and 2, respectively. Focal nodular hyperplasia had stimulated acoustic emission comparable to that of the liver in all cases; the median objective conspicuity score was -4.7% (all scores were <6%), and the subjective conspicuity score was I or lower for both observers, This finding completely separated focal nodular hyperplasia and malignancies. Significant differences were seen between focal nodular hyperplasia and all other lesion types (P < .05). CONCLUSION: Strong late-phase lesional uptake of SH U 508A is characteristic of focal nodular hyperplasia, is seen in some hemangiomas, and was not observed in malignancies.
引用
收藏
页码:661 / 667
页数:7
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