Tissue transglutaminase: apoptosis versus autoimmunity

被引：72

作者：

Piacentini, M ^{[1
]}

Colizzi, V

机构：

[1] Univ Rome Tor Vergata, Dept Biol, I-00173 Rome, Italy

[2] IRCCS L Spallanzani, Int Res Ctr AIDS & Other Emerging Infect, Rome, Italy

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(98)01416-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act ns substrates for the pro-apoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the pro-apoptotic enzyme tissue transglutaminase.

引用

页码：130 / 134

页数：5

共 60 条

[1]

Adyel FZ, 1996, J CLIN LAB ANAL, V10, P451

[2] Induction of ''tissue'' transglutaminase in HIV pathogenesis: Evidence for high rate of apoptosis of CD4(+) T lymphocytes and accessory cells in lymphoid tissues [J].

Amendola, A ;

Gougeon, ML ;

Poccia, F ;

Bondurand, A ;

Fesus, L ;

Piacentini, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :11057-11062

[3] CROSS-LINKING OF LIPOCORTIN-I AND ENHANCEMENT OF ITS CA-2+ SENSITIVITY BY TISSUE TRANSGLUTAMINASE [J].

ANDO, Y ;

IMAMURA, S ;

OWADA, MK ;

KAKUNAGA, T ;

KANNAGI, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (02) :944-951

[4] The association of tissue transglutaminase with human recombinant tau results in the formation of insoluble filamentous structures [J].

Appelt, DM ;

Balin, BJ .

BRAIN RESEARCH, 1997, 745 (1-2) :21-31

[5] Core histones are glutaminyl substrates for tissue transglutaminase [J].

Ballestar, E ;

Abad, C ;

Franco, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18817-18824

[6] Cell death mediators in autoimmune diabetes - No shortage of suspects [J].

Benoist, C ;

Mathis, D .

CELL, 1997, 89 (01) :1-3

[7] MACROPHAGE-COLONY-STIMULATING FACTOR (M-CSF) STIMULATION INDUCES CELL-DEATH IN HIV-INFECTED HUMAN MONOCYTES [J].

BERGAMINI, A ;

CAPOZZI, M ;

PIACENTINI, M .

IMMUNOLOGY LETTERS, 1994, 42 (1-2) :35-40

[8] THE CENTRAL ROLE OF CHROMATIN IN AUTOIMMUNE RESPONSES TO HISTONES AND DNA IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

BURLINGAME, RW ;

BOEY, ML ;

STARKEBAUM, G ;

RUBIN, RL .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :184-192

[9] Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus [J].

CasciolaRosen, L ;

Rosen, A ;

Petri, M ;

Schlissel, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (04) :1624-1629

[10] The intermediate filament protein, vimentin, in the lens is a target for cross-linking by transglutaminase [J].

Clément, S ;

Velasco, PT ;

Murthy, SNP ;

Wilson, JH ;

Lukas, TJ ;

Goldman, RD ;

Lorand, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (13) :7604-7609

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