Tissue transglutaminase: apoptosis versus autoimmunity

被引：72

作者：

Piacentini, M ^{[1
]}

Colizzi, V

机构：

[1] Univ Rome Tor Vergata, Dept Biol, I-00173 Rome, Italy

[2] IRCCS L Spallanzani, Int Res Ctr AIDS & Other Emerging Infect, Rome, Italy

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(98)01416-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases are characterized by multiple autoantibodies and/or autoreactive T cells that recognize a large number of antigens. Many of these antigens undergo extensive post-translational modifications during apoptosis and act ns substrates for the pro-apoptotic cystein proteases. Here, Mauro Piacentini and Vittorio Colizzi discuss the effects on autoimmunity produced by post-translational modifications of proteins catalysed by the pro-apoptotic enzyme tissue transglutaminase.

引用

页码：130 / 134

页数：5

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