Mining the Biodiversity of Plants: A Revolution in the Making

被引：249

作者：

De Luca, Vincenzo ^{[1
]}

Salim, Vonny ^{[1
]}

Atsumi, Sayaka Masada ^{[1
]}

Yu, Fang ^{[1
]}

机构：

[1] Brock Univ, Dept Biol Sci, St Catharines, ON L2S 3A1, Canada

来源：

SCIENCE | 2012年 / 336卷 / 6089期

基金：

加拿大自然科学与工程研究理事会;

关键词：

SACCHAROMYCES-CEREVISIAE; OPIUM POPPY; BENZYLISOQUINOLINE ALKALOIDS; MICROBIAL-PRODUCTION; BIOSYNTHESIS; YEAST; METABOLISM; MORPHINE; RESVERATROL; PATHWAY;

D O I：

10.1126/science.1217410

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Only a small fraction of the immense diversity of plant metabolism has been explored for the production of new medicines and other products important to human well-being. The availability of inexpensive high-throughput sequencing is rapidly expanding the number of species that can be investigated for the speedy discovery of previously unknown enzymes and pathways. Exploitation of these resources is being carried out through interdisciplinary synthetic and chemical biology to engineer pathways in plant and microbial systems for improving the production of existing medicines and to create libraries of biologically active products that can be screened for new drug applications.

引用

页码：1658 / 1661

页数：4

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