Withanolide compounds from the flower of Datura metel L.

被引：31

作者：

Yang, Bingyou ^{[1
]}

Wang, Qiuhong ^{[1
]}

Xia, Yonggang ^{[1
]}

Feng, Weisheng ^{[1
]}

Kuang, Haixue ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Harbin 150040, Peoples R China

来源：

HELVETICA CHIMICA ACTA | 2007年 / 90卷 / 08期

关键词：

D O I：

10.1002/hlca.200790159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three new withanolide compounds named baimantuoluoline A (1), B (2), and C (3) and the two known withanolides withafastuosin E (4) and withametelin C (5) were isolated from the fraction exhibiting activity for psoriasis in the flower of Datura metel L. The three new structures were determined as (5 alpha,6 alpha,7 alpha,12 beta,15 beta,22R)-6,7-epoxy-5,12,15-trihydroxy-l-oxowitha-2,24-dienolide (1), (5 alpha,6 beta,15 beta,22R)5,6,15,21-tetrahydroxy-1-oxowith-24-enolide (2), and (5 alpha,6 beta,12 beta,22R)-5,6,12,21-tetrahydroxy-27-methoxy-1-oxowitha-2,24-dienolide (3) on the basis of extensive spectroscopic data (HR-ESI-MS, H-1- and C-13-GNMR, H-1,H-1-COSY, HSQC, HMBC, and NOESY) (withanolide = 22-hydroxyergostan-26-oic acid delta-lactone).

引用

页码：1522 / 1528

页数：7

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