A new hypothesis of pathogenetic mechanism of viral hepatitis B and C

被引：27

作者：

Liu, DX ^{[1
]}

机构：

[1] NanFang Hosp, Dept Infect Dis, Guangzhou, Peoples R China

来源：

MEDICAL HYPOTHESES | 2001年 / 56卷 / 03期

关键词：

D O I：

10.1054/mehy.2000.1157

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The experimental data in recent years suggest apoptosis of liver cells plays a significant role in the pathogenesis of viral hepatitis. Firstly, the number of apoptotic hepatocytes in patients with hepatitis B or C is significantly higher than healthy objects. Secondly, the expression levels of Fas antigen in hepatocytes of patients with hepatitis B or C are closely correlated with inflammation activity. Thirdly, massive apoptosis of hepatocyte will result in fulminant hepatitis, while inhibition of apoptosis can prevent inflammation in experimental model of liver injury. And finally, the occurrence of hepatitis induced by CTL in transgenic mice is a process from hepatocyte apoptosis to liver necroinflammation. This paper will examine our current understanding of the possible relationship between hepatocellular apoptosis and the pathogenetic mechanism of hepatitis B and C. (C) 20010 Harcourt Publishers Ltd.

引用

页码：405 / 408

页数：4

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