A new twist in the transmembrane signaling tool-kit

被引：39

作者：

Lemmon, Mark A. ^{[1
]}

Ferguson, Kathryn M.

机构：

[1] Univ Penn, Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

来源：

CELL | 2007年 / 130卷 / 02期

关键词：

D O I：

10.1016/j.cell.2007.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In this issue, Schlessinger and his colleagues (Yuzawa et al., 2007) describe crystal structures of the complete extracellular region of the Kit receptor tyrosine kinase, both alone and in complex with its activating ligand, stem cell factor (SCF). The structures explain how SCF drives dimerization of the receptor. They also reveal important receptor-receptor contacts that may explain how several Kit mutations lead to cancer.

引用

页码：213 / 215

页数：3

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