Juxtamembrane autoinhibition in receptor tyrosine kinases

被引：236

作者：

Hubbard, SR ^{[1
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Pharmacol, New York, NY 10016 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1399

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Receptor tyrosine kinases are essential mediators of cell growth, differentiation, migration and metabolism. Accordingly, their catalytic activity is tightly regulated by several mechanisms including autoinhibition. Recent structural studies, together with biochemical experiments, are now unravelling the molecular mechanisms by which the juxtamembrane region ( between the transmembrane helix and the cytoplasmic kinase domain) negatively regulates catalytic activity in various receptor tyrosine kinases.

引用

页码：464 / 470

页数：7

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