Expression of translationally controlled tumor protein mRNA in human colon cancer

被引：64

作者：

Chung, S

Kim, M

Choi, WJ

Chung, JK

Lee, K ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Ctr Cell Signaling Res, Seoul 120750, South Korea

[2] Ewha Womans Univ, Div Mol Life Sci, Seoul 120750, South Korea

[3] Ewha Womans Univ, Dept Biol, Seoul 120750, South Korea

[4] Seoul Natl Univ, Coll Med, Seoul, South Korea

来源：

CANCER LETTERS | 2000年 / 156卷 / 02期

关键词：

translationally controlled tumor protein; colon cancer; Northern blot; yeast cell cycle; xenografted tumor;

D O I：

10.1016/S0304-3835(00)00460-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TCTP mRNA using a panel of normal human tissues. We also investigated the cell-cycle-dependent expression of the TCTP mRNA using synchronized cultures of Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon carcinoma cell lines and their tumors xenografted in a nude mouse was studied. Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：185 / 190

页数：6

共 18 条

[1] Differentially expressed genes in C6.9 glioma cells during vitamin D-induced cell death program [J].