Inhibition of mouse liver lipid peroxidation by high molecular weight phlorotannins from Sargassum kjellmanianum

被引：31

作者：

Wei, YX

Li, ZE ^{[1
]}

Hu, YF

Xu, ZH

机构：

[1] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

[3] Qingdao Univ, Dept Biol, Qingdao 266071, Peoples R China

来源：

JOURNAL OF APPLIED PHYCOLOGY | 2003年 / 15卷 / 06期

关键词：

phlorotannins; Sargassum kjellmanianum; liver; peroxidation;

D O I：

10.1023/B:JAPH.0000004344.45697.0f

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The inhibitory effects of high molecular weight phlorotannins (HMP) from Sargassum kjellmanianum on mouse liver lipid peroxidation were investigated by spectrophotometric methods. The content of malondialdehyde (MDA) in liver samples was measured by TBA (thiobarbituric acid) assay. It showed that HMP significantly inhibited the generation of MDA in vivo and in situations induced by CCl4 and Fe2+-Vc ( ascorbic acid), and significantly decreased membrane swelling of mouse liver mitochondria, compared with controls ( p < 0.01). HMP were found to have strong anti-oxidative activity in inhibiting mouse liver lipid peroxidation.

引用

页码：507 / 511

页数：5

共 19 条

[11]

Ragan M. A., 1986, PROG PHYCOL RES, V4, P129

[12] MECHANISMS OF CARBON-TETRACHLORIDE TOXICITY [J].