The IGF axis and hepatocarcinogenesis

被引：141

作者：

Scharf, JG

Dombrowski, F

Ramadori, G

机构：

[1] Univ Gottingen, Dept Med, Div Gastroenterol & Endocrinol, D-37075 Gottingen, Germany

[2] Univ Bonn, Inst Pathol, D-53127 Bonn, Germany

来源：

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2001年 / 54卷 / 03期

关键词：

insulin-like growth factors; insulin-like growth factor binding proteins; insulin-like growth factor I receptor; insulin-like growth factor II/mannose 6-phosphate receptor; hepatocarcinogenesis; hepatocellular carcinoma;

D O I：

10.1136/mp.54.3.138

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Deregulation of the insulin-like growth factor (IGF) axis, including the autocrine production of IGFs, IGF binding proteins (IGFBPs), IGFBP proteases, and the expression of the IGF receptors, has been identified in the development of hepatocellular carcinoma (HCC). Characteristic alterations detected in HCC and hepatoma cell Lines comprise the creased expression of IGF-II an IGF-I receptor (IGIF-IR), which nave emerged as crucial events in malignant transformation and the growth of tumours. Alterations of IGFBP production and the proteolytic degradation of IGFBPs resulting in an excess of bioactive IGFs, as well as the defective function of the IGF degrading IGF-II/mannose 6-phosphate receptor may further potentiate effects of IGFs in the HCC.

引用

页码：138 / 144

页数：7

共 103 条

[61] DIFFERENTIAL EXPRESSION OF TRANSFORMING GROWTH-FACTOR-ALPHA AND INSULIN-LIKE GROWTH-FACTOR-II IN CHRONIC ACTIVE HEPATITIS-B, CIRRHOSIS AND HEPATOCELLULAR-CARCINOMA [J].