Investigating interaction of ligands with voltage dependent anion channel through noise analyses

被引:8
作者
Banerjee, J [1 ]
Ghosh, S [1 ]
机构
[1] Univ Delhi, Dept Biophys, New Delhi 110021, India
关键词
noise analysis; BLM electrophysiology; VDAC; bax; plasminogen; phosphorylation;
D O I
10.1016/j.abb.2004.12.019
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ion channel-protein complexes inserted in the membrane act as molecular gates for transport across the membrane. The opening and closing of these gates can be controlled by one or more variables like ligands (small molecules, proteins, etc.), transmembrane voltage.. and the concentration gradient of a chemical across the membrane. We have shown how current noise profile of voltage dependent anion channel can be used to monitor change in the gating of the channel after its modulation by various ligands. This is being proposed as a novel method to probe the interaction of ion channels with ligands. (C) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:369 / 371
页数:3
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