Angiogenic factors in the central nervous system

被引：83

作者：

Harrigan, MR

机构：

[1] SUNY Buffalo, Sch Med & Biomed Sci, Dept Neurosurg, Buffalo, NY 14260 USA

[2] SUNY Buffalo, Sch Med & Biomed Sci, Toshiba Stroke Res Ctr, Buffalo, NY 14260 USA

来源：

NEUROSURGERY | 2003年 / 53卷 / 03期

关键词：

angiogenesis; arteriogenesis; brain tumor central nervous system; cerebrovascular disease;

D O I：

10.1227/01.NEU.0000079575.09923.59

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The past decade has seen considerable advances in the understanding of angiogenesis. Blood vessel development and growth in the central nervous system are tightly controlled processes that are regulated by angiogenic factors. Angiogenic factors have been implicated in the pathogensis of a wide variety of disorders, including primary and metastatic brain tumors, and therapeutic angiogenesis to promote collateral blood vessel formation among patients at risk of ischemia. This article summarizes the processes of blood vessel formation in the brain, examines the angiogenic factors that are prominent in the central nervous system, reviews the clinical use of angiogenesis inhibitors, and identifies areas for future investigation.

引用

收藏

页码：639 / 660

页数：22

相关论文

共 340 条

[1] Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma [J].

Abdulrauf, SI ;

Edvardsen, K ;

Ho, KL ;

Yang, XY ;

Rock, JP ;

Rosenblum, ML .

JOURNAL OF NEUROSURGERY, 1998, 88 (03) :513-520

[2] A COMPARISON OF NEUROTROPHIC EFFECTS OF EPIDERMAL GROWTH-FACTOR AND BASIC FIBROBLAST GROWTH-FACTOR IN PRIMARY CULTURED NEURONS FROM VARIOUS REGIONS OF FETAL-RAT BRAIN [J].

ABE, K ;

TAKAYANAGI, M ;

SAITO, H .

JAPANESE JOURNAL OF PHARMACOLOGY, 1990, 54 (01) :45-51

[3] Biodegradable polyglycolide endovascular coils promote wall thickening and drug delivery in a rat aneurysm model [J].

Abrahams, JM ;

Forman, MS ;

Grady, MS ;

Diamond, SL .

NEUROSURGERY, 2001, 49 (05) :1187-1193

[4] Activated microvessels express vascular endothelial growth factor and integrin αVβ3 during focal cerebral ischemia [J].

Abumiya, T ;

Lucero, J ;

Heo, JH ;

Tagaya, M ;

Koziol, JA ;

Copeland, BR ;

del Zoppo, GJ .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (09) :1038-1050

[5]

Achen MG, 2001, J PATHOL, V193, P147, DOI 10.1002/1096-9896(2000)9999:9999<::AID-PATH757>3.0.CO

[6]

2-G

[7] Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) [J].

Achen, MG ;

Jeltsch, M ;

Kukk, E ;

Mäkinen, T ;

Vitali, A ;

Wilks, AF ;

Alitalo, K ;

Stacker, SA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (02) :548-553

[8] Increased expression of transforming growth factor-β after cerebral ischemia in the baboon:: An endogenous marker of neuronal stress? [J].

Ali, C ;

Docagne, F ;

Nicole, O ;

Lesné, S ;

Toutain, J ;

Young, A ;

Chazalviel, L ;

Divoux, D ;

Caly, M ;

Cabal, P ;

Derlon, JM ;

MacKenzie, ET ;

Buisson, A ;

Vivien, D .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (07) :820-827

[9] VASCULAR ENDOTHELIAL GROWTH-FACTOR ACTS AS A SURVIVAL FACTOR FOR NEWLY FORMED RETINAL-VESSELS AND HAS IMPLICATIONS FOR RETINOPATHY OF PREMATURITY [J].

ALON, T ;

HEMO, I ;

ITIN, A ;

PEER, J ;

STONE, J ;

KESHET, E .

NATURE MEDICINE, 1995, 1 (10) :1024-1028

[10] Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1 - A potential mechanism for vascular permeability in diabetic retinopathy and tumors [J].

Antonetti, DA ;

Barber, AJ ;

Hollinger, LA ;

Wolpert, EB ;

Gardner, TW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (33) :23463-23467

← 1 2 3 4 5 6 7 8 9 10 →