Angiogenic factors in the central nervous system

被引：83

作者：

Harrigan, MR

机构：

[1] SUNY Buffalo, Sch Med & Biomed Sci, Dept Neurosurg, Buffalo, NY 14260 USA

[2] SUNY Buffalo, Sch Med & Biomed Sci, Toshiba Stroke Res Ctr, Buffalo, NY 14260 USA

来源：

NEUROSURGERY | 2003年 / 53卷 / 03期

关键词：

angiogenesis; arteriogenesis; brain tumor central nervous system; cerebrovascular disease;

D O I：

10.1227/01.NEU.0000079575.09923.59

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The past decade has seen considerable advances in the understanding of angiogenesis. Blood vessel development and growth in the central nervous system are tightly controlled processes that are regulated by angiogenic factors. Angiogenic factors have been implicated in the pathogensis of a wide variety of disorders, including primary and metastatic brain tumors, and therapeutic angiogenesis to promote collateral blood vessel formation among patients at risk of ischemia. This article summarizes the processes of blood vessel formation in the brain, examines the angiogenic factors that are prominent in the central nervous system, reviews the clinical use of angiogenesis inhibitors, and identifies areas for future investigation.

引用

页码：639 / 660

页数：22

共 340 条

[71] OVEREXPRESSION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR IN THE AVIAN EMBRYO INDUCES HYPERVASCULARIZATION AND INCREASED VASCULAR-PERMEABILITY WITHOUT ALTERATIONS OF EMBRYONIC PATTERN-FORMATION [J].