Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder

被引:223
作者
Kakiuchi, C
Iwamoto, K
Ishiwata, M
Bundo, M
Kasahara, T
Kusumi, I
Tsujita, T
Okazaki, Y
Nanko, S
Kunugi, H
Sasaki, T
Kato, T [1 ]
机构
[1] RIKEN, Brain Sci Inst, Lab Mol Dynam Mental Disorders, Wako, Saitama 3510198, Japan
[2] Hokkaido Univ, Dept Psychiat, Sapporo, Hokkaido 0608648, Japan
[3] Nagasaki Univ, Dept Psychiat, Nagasaki 8528523, Japan
[4] Mie Univ, Dept Psychiat, Tsu, Mie 5148507, Japan
[5] Teikyo Univ, Sch Med, Dept Psychiat, Itabashi Ku, Tokyo 1738605, Japan
[6] Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo 1878502, Japan
[7] Univ Tokyo, Hlth Serv Ctr, Dept Psychiat, Bunkyo Ku, Tokyo 1130033, Japan
关键词
D O I
10.1038/ng1235
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The pathophysiology of bipolar disorder is still unclear, although family, twin and linkage studies implicate genetic factors(1). Here we identified XBP1, a pivotal gene in the endoplasmic reticulum ( ER) stress response, as contributing to the genetic risk factor for bipolar disorder. Using DNA microarray analysis of lymphoblastoid cells derived from two pairs of twins discordant with respect to the illness, we found downregulated expression of genes related to ER stress response in both affected twins. A polymorphism (-116C-->G) in the promoter region of XBP1, affecting the putative binding site of XBP1, was significantly more common in Japanese patients ( odds ratio = 4.6) and overtransmitted to affected offspring in trio samples of the NIMH Bipolar Disorder Genetics Initiative. XBP1-dependent transcription activity of the -116G allele was lower than that of the -116C allele, and in the cells with the G allele, induction of XBP1 expression after ER stress was markedly reduced. Valproate, one of three mood stabilizers, rescued the impaired response by inducing ATF6, the gene upstream of XBP1. These results indicate that the -116C--> G polymorphism in XBP1 causes an impairment of its positive feedback system and increases the risk of bipolar disorder.
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收藏
页码:171 / 175
页数:5
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