Inflammatory processes in Alzheimer's disease

被引:423
作者
McGeer, EG [1 ]
McGeer, PL [1 ]
机构
[1] Univ British Columbia, Dept Psychiat, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada
基金
加拿大健康研究院;
关键词
inflammatory; complement; cytokines; microglia; pentraxins;
D O I
10.1016/S0278-5846(03)00124-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neuroinflammation is a characteristic of pathologically affected tissue in several neurodegenerative disorders. These changes are particularly observed in affected brain areas of Alzheimer's disease (AD) cases. They include an accumulation of large numbers of activated microglia and astrocytes as well as small numbers of T-cells, mostly adhering to postcapillary venules. Accompanying biochemical alterations include the appearance or up-regulation of numerous molecules characteristic of inflammation and free radical attack. Particularly important may be the complement proteins, acute phase reactants and inflammatory cytokines. These brain phenomena combined with epidemiological evidence of a protective effect of antiinflammatory agents suggest that such agents may have a role to play in treating the disease. (C) 2003 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:741 / 749
页数:9
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