Mammalian Groucho homologs: Redundancy or specificity?

被引：97

作者：

Gasperowicz, M

Otto, F

机构：

[1] Univ Freiburg, Med Ctr, Div Haematol & Oncol, Dept Internal Med, D-79106 Freiburg, Germany

[2] Univ Freiburg, Inst Biol 3, D-79106 Freiburg, Germany

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2005年 / 95卷 / 04期

关键词：

Groucho; TLE; Grg; corepressor; transcriptional regulation;

D O I：

10.1002/jcb.20476

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proteins termed TLE in humans, Grg in mice and Groucho in Drosophila constitute a family of transcriptional corepressors. In mammalians there are five different genes encoding an even larger number of proteins. Interactions between these TLE/Grg proteins and an array of transcription factors has been described. But is there any specificity? This review tries to make a case for a non-redundant function of individual TLE/Grg proteins. The specificity may be brought about by a tightly controlled temporo-spatial expression pattern, post-translational modifications, and subtle structural differences leading to distinct preferences for interacting transcription factors. A confirmation of this concept will ultimately need to come from genetic experiments. (c) 2005 Wiley-Liss, Inc.

引用

页码：670 / 687

页数：18

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