Regulation of gene expression by synthetic DNA-binding ligands

被引:76
作者
Dervan, PB [1 ]
Poulin-Kerstien, AT [1 ]
Fechter, EJ [1 ]
Edelson, BS [1 ]
机构
[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
来源
DNA BINDERS AND RELATED SUBJECTS | 2005年 / 253卷
关键词
polyamide; DNA; gene regulation;
D O I
10.1007/b100440
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
During the past 20 years, polyamides have evolved from the natural product distamycin to a new class of programmable heterocyclic oligomers that bind a broad repertoire of DNA sequences with high affinity and specificity. This chapter details recent advances in this field of research, focusing on molecular recognition of DNA, and biological applications such as modulating gene expression by small molecules. Work presented here represents efforts towards the modulation of specific cellular function by small molecules in an addressable fashion within the context of live cells.
引用
收藏
页码:1 / 31
页数:31
相关论文
共 110 条
  • [1] RNAi and related mechanisms and their potential use for therapy
    Agami, R
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (06) : 829 - 834
  • [2] Towards a minimal motif for artificial transcriptional activators
    Ansari, AZ
    Mapp, AK
    Nguyen, DH
    Dervan, PB
    Ptashne, M
    [J]. CHEMISTRY & BIOLOGY, 2001, 8 (06): : 583 - 592
  • [3] STRUCTURE + SYNTHESIS OF DISTAMYCIN A
    ARCAMONE, F
    NICOLELL.V
    PENCO, S
    OREZZI, P
    PIRELLI, A
    [J]. NATURE, 1964, 203 (494) : 1064 - +
  • [4] Toward artificial developmental regulators
    Arndt, HD
    Hauschild, KE
    Sullivan, DP
    Lake, K
    Dervan, PB
    Ansari, AZ
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (44) : 13322 - 13323
  • [5] Design of artificial transcriptional activators with rigid poly-L-proline linkers
    Arora, PS
    Ansari, AZ
    Best, TP
    Ptashne, M
    Dervan, PB
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (44) : 13067 - 13071
  • [6] Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids
    Baird, EE
    Dervan, PB
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (26) : 6141 - 6146
  • [7] Kinetic consequences of covalent linkage of DNA binding polyamides
    Baliga, R
    Baird, EE
    Herman, DM
    Melander, C
    Dervan, PB
    Crothers, DM
    [J]. BIOCHEMISTRY, 2001, 40 (01) : 3 - 8
  • [8] Solid-phase synthesis of DNA binding polyamides on oxime resin
    Belitsky, JM
    Nguyen, DH
    Wurtz, NR
    Dervan, PB
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (08) : 2767 - 2774
  • [9] Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates
    Belitsky, JM
    Leslie, SJ
    Arora, PS
    Beerman, TA
    Dervan, PB
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (10) : 3313 - 3318
  • [10] CAMPTOTHECIN-STABILIZED TOPOISOMERASE-I-DNA ADDUCTS CAUSE PREMATURE TERMINATION OF TRANSCRIPTION
    BENDIXEN, C
    THOMSEN, B
    ALSNER, J
    WESTERGAARD, O
    [J]. BIOCHEMISTRY, 1990, 29 (23) : 5613 - 5619