Treatment with docosahexaenoic acid after hypoxia-ischemia improves forepaw placing in a rat model of perinatal hypoxia-ischemia

被引：24

作者：

Berman, Deborah R. ^{[1
]}

Liu, YiQing ^{[2
]}

Barks, John ^{[2
]}

Mozurkewich, Ellen ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Div Maternal Fetal Med, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Div Neonatol, Dept Pediat, Ann Arbor, MI USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 04期

关键词：

docosahexaenoic acid; hypoxia-ischemia; neuroprotection; perinatal rescue therapy; BIRTH ASPHYXIA; MEDIATED NEUROPROTECTION; BRAIN-DAMAGE; TOPIRAMATE; STROKE; INJURY;

D O I：

10.1016/j.ajog.2010.06.017

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Docosahexaenoic acid (DHA) is a dietary fatty acid with neuroprotective properties. We hypothesized that DHA treatment after hypoxia-ischemia would improve function and reduce brain volume loss in a perinatal rat model. STUDY DESIGN: Seven-day-old Wistar rat pups from 7 litters (n = 84) underwent right carotid ligation, followed by 8% O-2 for 90 minutes. Fifteen minutes after hypoxia-ischemia, pups were divided into 3 treatment groups (intraperitoneal injections of DHA 1, 2.5, or 5 mg/kg) and 2 control groups (25% albumin or saline). At 14 days, rats underwent vibrissae-stimulated forepaw placing testing, and bilateral regional volumes were calculated for cortex, striatum, hippocampus, and hemisphere. RESULTS: Posthypoxia-ischemia treatment with DHA acid significantly improved vibrissae forepaw placing (complete responses: 8.5 +/- 2 treatment vs 7.4 +/- 2 controls; normal = 10; P = .032, t test). Postinjury DHA treatment did not attenuate brain volume loss in any region. CONCLUSION: Posthypoxia-ischemia DHA treatment significantly improves functional outcome.

引用

页码：385.e1 / 385.e5

页数：5

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