SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases

被引：131

作者：

Mertens, S ^{[1
]}

Craxton, M ^{[1
]}

Goedert, M ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

FEBS LETTERS | 1996年 / 383卷 / 03期

关键词：

mitogen-activated protein kinase; stress-activated protein kinase; stress-activated protein kinase-3; HOG1;

D O I：

10.1016/0014-5793(96)00255-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stress-activated protein kinases are MAP kinase homologues that are activated by cellular stresses, bacterial endotoxin and inflammatory cytokines, They are activated by a dual threonine/tyrosine phosphorylation within a TPY sequence in the case of stress-activated protein kinase-1 and its isoforms (also called JNKs) or a TGY sequence in the case of stress-activated protein kinase-2 and its isoforms (also called p38, p40, RK, CSBPs, XMpk2 and Mxi2), Here we report the cloning and sequencing of a new protein kinase from rat with a TGY sequence in the activation domain, This stress-activated protein kinase-3 is 60% identical to mouse stress-activated protein kinase-2 and 45% identical to HOG1 from Saccharomyces cerevisiae. Transcripts encoding stress-activated protein kinase-3 are widely expressed, with high levels in skeletal muscle.

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页码：273 / 276

页数：4

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