Gap junction wiring: a 'new' principle in cell-to-cell communication in the nervous system?

被引：91

作者：

Dermietzel, R ^{[1
]}

机构：

[1] Univ Regensburg, Inst Anat, D-93052 Regensburg, Germany

来源：

BRAIN RESEARCH REVIEWS | 1998年 / 26卷 / 2-3期

关键词：

molecular neuroscience; electrical synapses; gap junctions; glia; intercellular volume transmission; interneuronal communication;

D O I：

10.1016/S0165-0173(97)00031-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review gives an updated excerpt of recent advances in our understanding of brain gap junctions. It starts with a brief description of the principle molecular composition of gap junctions before specific issues concerning brain tissues are addressed. The following questions and matters are subjected to a detailed analysis: First, why are there so many gap junctions in the brain? Second, what is the functional significance of the cellular diversity of brain gap junctions? Third, how do astrocytic gap junctions mediate intercellular volume transmission (IVT), and what does IVT mean for glial-neuronal interaction? Fourth, how frequent are interneuronal gap junctions; and what is their functional significance in brain development and in interrelated chemical-electrotonic transmission at mixed synapses. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：176 / 183

页数：8

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