A novel method for the one-pot three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones

被引：142

作者：

Salehi, P

Dabiri, M

Zolfigol, MA

Baghbanzadeh, M

机构：

[1] Shahid Beheshti Univ, Dept Phytochem, Med Plants & Drugs Res Inst, Tehran 1983963113, Iran

[2] Shahid Beheshti Univ, Fac Sci, Dept Chem, Tehran 1983963113, Iran

[3] Bu Ali Sina Univ, Fac Sci, Dept Chem, Hamadan 65174, Iran

来源：

SYNLETT | 2005年 / 07期

关键词：

silica sulfuric acid; heterocycles; 2,3-dihydroquinazolin-4(1H)-ones; catalysis; isatoic anhydride;

D O I：

10.1055/s-2005-865200

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot three-component condensation of isatoic anhydride with primary amines or ammonium carbonate and aromatic aldehydes in refluxing ethanol in the presence of catalytic amounts of silica sulfuric acid afforded the corresponding 2.3-dihydroquinazolin-4(1H)-ones in high yields. The catalyst is reusable and can be applied several times without any decrease in product yield.

引用

页码：1155 / 1157

页数：3

共 37 条

[1] A novel method for the synthesis of 4(3H)-quinazolinones [J].

Abdel-Jalil, RJ ;

Voelter, W ;

Saeed, M .

TETRAHEDRON LETTERS, 2004, 45 (17) :3475-3476

[2] Multiple-component condensation strategies for combinatorial library synthesis [J].

Armstrong, RW ;

Combs, AP ;

Tempest, PA ;

Brown, SD ;

Keating, TA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :123-131

[3]

ASAKAWA H, 1979, CHEM PHARM BULL, V27, P1287

[4]

Asinex, 1982, [No title captured], Patent No. [EP 0058822 A1, 0058822]

[5] AN ANTIMALARIAL ALKALOID FROM HYDRANGEA .18. DERIVATIVES OF 4-PYRIMIDONE [J].

BAKER, BR ;

SCHAUB, RE ;

JOSEPH, JP ;

MCEVOY, FJ ;

WILLIAMS, JH .

JOURNAL OF ORGANIC CHEMISTRY, 1953, 18 (02) :133-137

[6]

Bhalla P.R., 1984, US Patent, Patent No. [44,314,40 A 19840214, 4431440]

[7]

BIRESSI MG, 1969, FARMACO-ED SCI, V24, P199

[8]

Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO

[9]

2-U

[10]

GRAVIER D, 1992, PHARMAZIE, V47, P91

← 1 2 3 4 →