MICRORNAS IN DROSOPHILA DEVELOPMENT

被引：48

作者：

Chawla, Geetanjali ^{[1
]}

Sokol, Nicholas S. ^{[1
]}

机构：

[1] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 286 | 2011年 / 286卷

关键词：

microRNA; miRNA; Transcriptional regulation; Drosophila; Development; dsRNA; MEDIATES NUCLEAR EXPORT; DSRNA-BINDING-PROTEIN; SMALL TEMPORAL RNAS; POSTTRANSCRIPTIONAL REGULATION; CELL-PROLIFERATION; TARGET PREDICTION; BANTAM MICRORNA; MESSENGER-RNAS; FUNCTIONAL ANNOTATION; COMPUTATIONAL METHODS;

D O I：

10.1016/B978-0-12-385859-7.00001-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Micro-ribonucleic acids (miRNAs) are small (21-24 nucleotide), endogenously expressed, noncoding RNAs that have emerged as important posttranscriptional regulators of gene expression. MiRNAs have been identified and cloned from diverse eukaryotic organisms where they have been shown to control important physiological and developmental processes such as apoptosis, cell division, and differentiation. A high level of conservation of some miRNAs across phyla further emphasizes their importance as posttranscriptional regulators. Research in a variety of model systems has been instrumental in dissecting the biological functions of miRNAs. In this chapter, we discuss the current literature on the role of miRNAs as developmental regulators in Drosophila.

引用

页码：1 / 65

页数：65

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