Integrated profiling of diffuse large B-cell lymphoma with 7q gain

被引：10

作者：

Chigrinova, Ekaterina ^{[1
,2
]}

Mian, Michael ^{[1
,2
,3
]}

Shen, Yulei ^{[4
]}

Greiner, Timothy C. ^{[4
]}

Chan, Wing C. ^{[4
]}

Vose, Julie M. ^{[4
]}

Inghirami, Giorgio ^{[5
,6
]}

Chiappella, Annalisa ^{[7
]}

Baldini, Luca ^{[8
]}

Ponzoni, Maurilio ^{[9
]}

Ferreri, Andres J. M. ^{[9
]}

Franceschetti, Silvia ^{[10
,11
]}

Gaidano, Gianluca ^{[10
,11
]}

Tucci, Alessandra ^{[12
,13
]}

Facchetti, Fabio ^{[12
,13
]}

Lazure, Thierry ^{[14
,15
]}

Lambotte, Olivier ^{[14
,15
]}

Montes-Moreno, Santiago ^{[16
]}

Piris, Miguel A. ^{[16
]}

Zucca, Emanuele ^{[1
,2
]}

Kwee, Ivo ^{[1
,2
,17
]}

Bertoni, Francesco ^{[1
,2
]}

机构：

[1] Oncol Inst So Switzerland IOSI, Expt Oncol Lab, CH-6500 Bellinzona, Switzerland

[2] Oncol Inst So Switzerland IOSI, Lymphoma Unit, CH-6500 Bellinzona, Switzerland

[3] Azienda Osped S Maurizio, Div Hematol, Bolzano, Italy

[4] Univ Nebraska, Dept Pathol & Microbiol, Omaha, NE 68182 USA

[5] Univ Turin, Dept Pathol, Turin, Italy

[6] Univ Turin, Ctr Expt Res & Med Studies CeRMS, Turin, Italy

[7] AOU San Giovanni Battista, Hematol Sect 2, Dept Hematol & Oncol, Turin, Italy

[8] Univ Milan, Hematol Bone Marrow Transplantat Unit, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[9] Ist Sci San Raffaele, Unit Lymphoid Malignancies, Milan, Italy

[10] Amedeo Avogadro Univ Eastern Piedmont, Div Hematol, Dept Clin & Expt Med, Novara, Italy

[11] Amedeo Avogadro Univ Eastern Piedmont, BRMA, Novara, Italy

[12] Univ Brescia, Dept Pathol, Serv Anat Patol 1, Brescia, Italy

[13] Spedali Civil Brescia, Div Hematol, I-25125 Brescia, Italy

[14] Univ Hosp Bicetre, AP HP, Dept Internal Med, Le Kremlin Bicetre, France

[15] Univ Hosp Bicetre, AP HP, Dept Pathol, Le Kremlin Bicetre, France

[16] Spanish Natl Canc Res Ctr CNIO, Mol Pathol Programme, Madrid, Spain

[17] Dalle Molle Inst Artificial Intelligence, Manno, Switzerland

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2011年 / 153卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

gain; miRNA; Affymetrix; aggressive lymphoma; bone marrow; COPY NUMBER; EXPRESSION; PREDICTION; SUBGROUPS; MICRORNAS; PATHWAYS; SET;

D O I：

10.1111/j.1365-2141.2011.08628.x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

P>To characterize diffuse large B-cell lymphoma (DLBCL) with chromosome 7 gains, we combined clinical data with genomic, RNA and miRNA profiling. Gains were associated with age > 60 years, female gender, a trend for higher complete response rate, lower death rate, and better overall survival in patients treated with R-CHOP. Lesions were inversely associated with bone marrow involvement and number of extra-nodal sites. Differentially expressed transcripts were enriched of genes belonging to specific pathways and miRNAs targets. MIR96, MIR182, MIR589, MIR25 were shown significantly up-regulated in 7q+ DLBCL by real-time PCR.

引用

页码：499 / 503

页数：5

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